Current status on Alzheimer disease molecular genetics: from past, to present, to future
Identifieur interne : 000E24 ( Main/Exploration ); précédent : 000E23; suivant : 000E25Current status on Alzheimer disease molecular genetics: from past, to present, to future
Auteurs : Karolien Bettens [Belgique] ; Kristel Sleegers [Belgique] ; Christine Van Broeckhoven [Belgique]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2010-04-15.
Abstract
Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genesamyloid precursor protein and presenilin 1 and 2 genesand one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
Url:
DOI: 10.1093/hmg/ddq142
Affiliations:
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<front><div type="abstract">Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genesamyloid precursor protein and presenilin 1 and 2 genesand one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.</div>
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